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Antonio V. Ferrer Montiel's group

Publicatons of the group (last years).

Giudici AM, Molina ML, Ayala JL, Montoya E, Renart ML, Fernández AM, Encinar JA, Ferrer-Montiel AV, Poveda JA, González-Ros JM. Detergent-labile, supramolecular assemblies of KcsA: Relative abundance and interactions involved. Biochim Biophys Acta. 2012 Sep 27;1828(2):193-200.

Renart ML, Montoya E, Fernández AM, Molina ML, Poveda JA, Encinar JA, Ayala JL, Ferrer-Montiel AV, Gómez J, Morales A, González Ros JM. Contribution of ion binding affinity to ion selectivity and permeation in KcsA, a model potassium channel. Biochemistry. 2012 May 8;51(18):3891-900. Epub 2012 Apr 27.

Navarro A, Encinar JA, López-Méndez B, Aguado-Llera D, Prieto J, Gómez J, Martínez-Cruz LA, Millet O, González-Ros JM, Fernández-Ballester G, Neira JL, Ferrer-Montiel A. Mutation of Ser-50 and Cys-66 in Snapin Modulates Protein Structure and Stability. Biochemistry. 2012 Apr 11. [Epub ahead of print]

Sanz-Salvador L, Andrés-Borderia A, Ferrer-Montiel A, Planells-Cases R. Agonist- and Ca2+-dependent desensitization of TRPV1 channel targets the receptor to lysosomes for degradation. J Biol Chem. 2012 Jun 1;287(23):19462-71. Epub 2012 Apr 6.

Ferrer-Montiel A, Fernández-Carvajal A, Planells-Cases R, Fernández-Ballester G, González-Ros JM, Messeguer A, González-Muñiz R. Advances in modulating thermosensory TRP channels.Expert Opin Ther Pat. 2012 Sep;22(9):999-1017. Epub 2012 Jul 27.

Ponsati B, Carreño C, Curto-Reyes V, Valenzuela B, Duart MJ, Van den Nest W, Cauli O, Beltran B, Fernandez J, Borsini F, Caprioli A, Di Serio S, Veretchy M, Baamonde A, Menendez L, Barros F, de la Pena P, Borges R, Felipo V, Planells-Cases R, Ferrer-Montiel A. An inhibitor of neuronal exocytosis (DD04107) displays long-lasting in vivo activity against chronic inflammatory and neuropathic pain. J Pharmacol Exp Ther. 2012 Jun;341(3):634-45. Epub 2012 Mar 5.

Vidal-Mosquera M, Fernández-Carvajal A, Moure A, Valente P, Planells-Cases R, González-Ros JM, Bujons J, Ferrer-Montiel A, Messeguer A. (2011) Triazine-based vanilloid 1 receptor open channel blockers: design, synthesis, evaluation, and SAR analysis. J Med Chem.54(21):7441-52.

Zaccaro L, García-López MT, González-Muñiz R, García-Martínez C, Ferrer-Montiel A, Albericio F, Royo M. TRPV1 modulators: structure-activity relationships using a rational combinatorial approach.Bioorg Med Chem Lett. 2011 Jun 15;21(12):3541-5.

Gerona-Navarro G, González-Muñiz R, Fernández-Carvajal A, González-Ros JM, Ferrer-Montiel A, Carreño C, Albericio F, Royo M. Solid-phase synthesis of a library of amphipatic hydantoins. Discovery of new hits for TRPV1 blockade. ACS Comb Sci. 2011 Sep 12;13(5):458-65.

Valente P, Fernández-Carvajal A, Camprubí-Robles M, Gomis A, Quirce S, Viana F, Fernández-Ballester G, González-Ros JM, Belmonte C, Planells-Cases R, Ferrer-Montiel A. Membrane-tethered peptides patterned after the TRP domain (TRPducins) selectively inhibit TRPV1 channel activity.FASEB J. 2011 May;25(5):1628-40.

Planells-Cases R, Valente P, Ferrer-Montiel A, Qin F, Szallasi A.Complex regulation of TRPV1 and related thermo-TRPs: implications for therapeutic intervention.Adv Exp Med Biol. 2011;704:491-515.

Mª Jesús Pérez de Vega , Mª Teresa García-López , Laura Zaccaro , Miriam Royo , Fernando Albericio, Asia Fernández-Carvajal , Antonio Ferrer-Montiel and Rosario González-Muñiz Solid-Phase Synthesis of New Trp(Nps)-Containing Dipeptide Derivatives as TRPV1 Channel Blockers, Molecules 2010, 15, 4924-4933

Camprubí-Robles M, Planells-Cases R, Ferrer-Montiel A. Differential contribution of SNARE-dependent exocytosis to inflammatory potentiation of TRPV1 in nociceptors. FASEB J. (2009) Jul 7.

Quintanar-Audelo, M., Fernández-Carvajal, A., Van Den Nest, W, Carreño, C., *Ferrer-Montiel, A and *Albericio, A. (2007) Design and synthesis of indole based peptoids as potent TRPV1 antagonists (*Co-corresponding authors). J. Med. Chem. 50, 6133-6143.

García-Sanz, N., Valente, P. Gomis, A., Fernández-Carvajal, A., Fernández-Ballester, G., Viana, F., Belmonte, C. and Ferrer-Montiel, A. (2007) A role of the transient receptor potential domain of vanilloid receptor 1 in channel gating. J. Neurosci. 27, 11641-11650.

Planells-Cases R and Ferrer-Montiel, A. (2007) Drug design and development through the vanilloid receptor. Expert Opin. Drug Discovery 2, 1053-1063.

Bonache, MA, García-Martínez, C., García de Diego, L, Carreño, C., Pérez de Vega, M.J., García-López, M.T., Ferrer-Montiel, A. and González-Muñiz, R. (2006) Old Molecules for new receptors: Trp(Nps) dipeptide derivatives as vanilloid TRPV1 channel blockers. Chem. Med. Chem. 1, 429-438.

Garcia-Martinez, C., Fernández-Carvajal, A., Valenzuela, B., Gomis, A., Van den Nest, W., Ferroni, S., Carreño, C., Belmonte, C. and Ferrer-Montiel, A. (2006) Design and characterization of a non-competitive antagonist of the TRPV1 channel with in vivo analgesic and anti-inflammatory activity. J. of Pain 7, 735-746.

Planells-Cases, R. and Ferrer-Montiel, A. (2006) Trafficking of TRP channels. TRP ion channels function in sensory transduction and cellular signalling cascades (Invited Revision). Frontiers in Neuroscience (CRC Presss), 319-330.

Planells-Cases, R., Lerma, J. and Ferrer-Montiel, A. (2006) Pharmacology of Ionotropic Glutamate Receptors. Curr. Pharm. Design 12, 3583-3596.

Messeguer, A., Planells-Cases, R. and Ferrer-Montiel, A. (2006) Physiology and Pharmacology of the Vanilloid receptor. Curr. Neuropharmacol. 4, 1-15.

Planells-Cases, R., Garcia-Sanz, N., Morenilla-Palao, C. and Ferrer-Montiel, A. (2005) Functional aspects and mechanisms of TRPV1 involvement in neurogenic inflammation that leads to thermal hyperalgesia. Pflugers Arch. 451, 151-159.

Caprini, M, Fava, M., Valente, P., Fernández-Ballester, G., Rapisarda, C., Ferroni, S. and Ferrer-Montiel, A. (2005) Molecular compatibility of the channel gate and the N-terminus of S5 segment for voltage-gated channel activity. J. Biol. Chem. 280, 18253-18264.

García-Sanz, N., Fernández-Carvajal, C., Morenilla-Palao, C., Planells-Cases, R., Fajardo-Sanchez, E., Fernández-Ballester, G. and Ferrer-Montiel, A (2004) Identification of a tetramerization domain in the C-terminus of the vanilloid receptor. J. Neurosci. 24, 5307-5314.

Morenilla-Palao, C, Planells-Cases, R., García-Sanz, N. and Ferrer-Montiel, A. (2004) Title: Regulated exocytosis contributes to protein kinase C potentiation of vanilloid receptor activity. J. Biol. Chem. 279, 25665- 25672.

Blanes-Mira, C., Merino, J.M., Valera, E., Fernández-Ballester, G., Gutiérrez, L.M., Viniegra, S., Pérez-Payá, E. and Ferrer-Montiel, A. (2004) Small peptides patterned after the N-terminus domain of SNAP25 inhibit SNARE complex assembly and regulated exocytosis. J. Neurochemistry 88, 124-135.

Blanes-Mira, C., Pastor, M.T., Valera, E., Fernández-Ballester, G., Merino, J.M., Gutiérrez, L.M., Pérez-Payá, E. and Ferrer-Montiel, A. (2003) Identification of SNARE complex modulators that inhibit exocytosis from an a-helix-constrained combinatorial library. Biochem J. 375: 159-166.

Planells-Cases, R., Montoliu, C., Humet, M., Fernández, A., García-Martínez, C., Valera, E., Merino, J.M., Pérez-Payá, E., Messeguer, A, Felipo, V., and Ferrer-Montiel, A. (2002) A novel N-methyl-D-aspartate receptor open channel blocker with in vivo neuroprotectant activity. J. Pharmacol. Exp. Ther. 302, 163-173.

García-Martínez, C., Humet, M., Planells-Cases, R., Gomis, A., Caprini, M., Viana, F., De la Peña, E., Sanchez-Baeza, F., Carbonell, T., De Felipe, C., Pérez-Payá, E., Belmonte, C., Messeguer, A. and Ferrer-Montiel, A. (2002) Attenuation of thermal nociception and hyperalgesia by VR1 blockers. Proc. Natl. Acad. Sci. USA 99, 2374-2379.

Caprini, M., Ferroni, S., Planells-Cases, R., Rueda, J., Rapisarda, C., 1Ferrer-Montiel, A. and Montal, M. 1Corresponding author. (2001) Structural compatibility between the putative voltage sensor of voltage-gated K+ channels and the prokaryotic KcsA channel. J. Biol. Chem. 276, 21070- 21076.

García-Martínez, C., Morenilla-Palao, C., Planells-Cases, R., Merino, J.M., and Ferrer-Montiel, A. (2000) Identification of an aspartic residue in the P-loop of the vanilloid receptor that modulates pore properties. J. Biol. Chem. 275, 32552-32558.

Planells-Cases, R., Aracil, A., Merino, J.M., Gallar, J., Pérez-Payá, E., Belmonte, C., González-Ros, J.M. and Ferrer-Montiel, A. (2000) Arginine-rich peptides are blockers of VR-1 channels with analgesic activity. FEBS Lett. 481, 131-136.

Ferrer-Montiel, A.V., Merino, J.M., Planells-Cases, R., Sun, W, and Montal. M. (1998) Structural determinants of the blocker binding site in glutamate and NMDA receptor channels. Neuropharmacology 37, 139-147.

Ferrer-Montiel, A.V., Merino, J.M., Blondelle, S.E., Perez-Paya, E., Houghten, R.A. and Montal, M. (1998) Selected peptides targeted to the NMDA receptor channel protect neurons from excitotoxic death. Nature Biotechnology 16, 286-291.

Ferrer-Montiel, A.V., Sun, W. and Montal, M. (1996) A single tryptophan on M2 of glutamate receptor channels confers high permeability to divalent cations. Biophys. J. 71, 749-758.

†Planells-Cases, R., †Ferrer-Montiel, A.V., Patten, C.D. and Montal, M. (1995) Mutation of conserved negatively charged residues in the S2 and S3 transmembrane segments of mammalian K+ channel selectively modulates channel gating. (†R.P.-C. and A.V.F.M. First author). Proc. Natl. Acad. Sci. USA 92, 9422-9426.

Ferrer-Montiel, A.V., Sun, W. and Montal, M. (1995) Molecular design of the N-methyl-D-aspartate receptor binding site for phencyclidine and dizolcipine. Proc. Natl. Acad. Sci. USA. 92, 8021-8025

Ferrer-Montiel, A.V. and Montal, M. (1994) Structure-function relations in ligand-gated ion channels: Reconstitution in lipid bilayers and heterologous expression in Xenopus oocytes. Methods: a Companion to Methods in Enzymology 6, 60-69.

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