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Angel Messeguer

Name: Messeguer, AngelDr. Angel Messeger
Citizenship: Spanish
Institution: Consejo Superior de Investigaciones Científicas
Center: Institute for Advanced Chemistry of Catalonia
Address: J. Girona, 18. E-08034 Barcelona. Spain.
Phone: + 34 93-400 6121
Fax: + 34 93-205 5904
angel.messeguer@iqac.csic.es
http://www.iiqab.csic.es/indexgrup.php?pIdGrup=8&pIdioma=ENG&pFrom=iiqab 

Research

The scientific results achieved by our group are displayed in the list of publications enclosed in the corresponding Section. Moreover, in the last five years seven graduate students have reached their PhD degree and ten undergraduate students their Master degree. On the other hand, we participate in a patent on the application of an antioxidant discovered in this laboratory in antitumoral therapy. Five more patents related to molecules with potential biomedical applications derived from combinatorial libraries have been issued.

Our main research focus is on combinatorial chemistry of low molecular weight molecules. With this aim, we have established a close collaboration with different groups from Academia and pharmaceutical companies. Our objectives cover the application of combichem technology for the construction of libraries of biomedical interest. Two libraries of controlled mixtures of peptoids, the first one containing over 10.000 compounds and the second one over 5.000, have been constructed. These libraries have been screened by different groups and hits in neuroprotection, analgesia, neuron regeneration, antimicrobials, LPS and on different cancer targets, have been identified. The synthesis of focused libraries addressed to optimise the pharmacological properties of the most active of these hits are in due course. On the other hand, three libraries of individual compounds containing heterocyclic structures have been also synthesised. In addition to other libraries planned or under current development, our group remains open to establish agreements with research groups from academia or pharmaceutical and biotechnology companies for testing this library portfolio and for synthesising new libraries under specific demand. Overall, our expertise covers combinatorial libraries of either controlled mixtures or individual compounds formats. Concerning the methodological aspects, both solid-phase and solution chemistries have been explored. More recently, in silico techniques for the design and virtual screening of combinatorial libraries have been implemented to strength our capabilities. These techniques are currently applied for discovering new leads in the analgesia and cancer therapeutic areas. A recent project deals also with apoptosis. We are interested in the protein-protein interactions where cytochrome C plays a crucial role. Our goals are the development of novel apoptosis agonists for application in the cancer area and apoptosis inhibitors for the treatment of neurodegenerative disorders.

Other topics explored in our laboratory are related to bioactive organic compounds. The search of mechanisms responsible of the cytotoxic activity elicited by environmental pollutants and the study of antioxidants and lipid peroxide inhibitors, have been also subject of our interest in recent years. Likewise, we are performing studies on the design and development of new oxidation biocatalysts based on hemoproteins. In particular, we are interested in hemopeptides exhibiting peroxidase and monooxyhenase activities and their application in Organic Synthesis.

Finally, our laboratory has been committed by the Toxic Oil Syndrome Program (World Health Organisation) to supply with synthetic standards and substrates to all worldwide groups that are investigating this intoxication episode. In this same context, our group has been working actively on the development of a model oil containing the putative toxic compounds in amounts comparable to those present in the real toxic oil batches, and on the identification of metabolites from compounds considered responsible for the toxicity elicited by the fraudulent oil.


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