Name: Rodríguez Artalejo, Antonio
Institution: Complutense University of Madrid
Center: School of Veterinary Science
Address: Dept. Toxicology and Pharmacology
Av. Puerta de Hierro s/n
28040 Madrid. Spain
Phone: + 34 91 394 3851
Fax: + 34 91 394 3851
Our team is primarily interested in defining the role of certain classes of ionic channels in stimulus-secretion coupling from neurons and neurosecretory cells.
We are currently working on the following topics:
1. Biophysical, pharmacological and functional characterization of nicotinic cholinergic receptors involved in transmission at the splanchnic nerve-adrenomedullary chromaffin cell junction. In turn, this goal comprises three different issues:
1.1. Identification of novel nicotinic receptor types -particularly, those containing a9 and a10 subunits- potentially involved in transmission at that synapse.
1.2. The role of presynaptic nicotinic receptors in regulating acetylcholine release from splanchnic nerve terminals.
1.3. Changes in nicotinic receptor expression and function induced by subacute stress.
2. Calcium-independent activation of BK channels from chromaffin cells under physiological voltages. Recent results from our laboratory suggest that BK channels might influence de duration of action potentials independently of a rise in cytosolic calcium. In the near future our work will aim at defining the physiological significance of a purely voltage-dependent activation of BK channels.
3. Pharmacological and biophysical characterization of purinergic P2X receptors in cerebellar Purkinje and granule neurons as well as neuroblastoma cells. In collaboration with the group led by Prof. Miras Portugal we are addressing their functional significances with regard to calcium signalling and exocytosis of both hormones and neurotransmitters.