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Date
10/12/2011 13:48:00
Group number
PI name
Messeguer, A.
Channel family
TRP
Channel name
TRPV1
Channel subunit
UNIPROT
Relevant publication (1)
Relevant publication (2)
Relevant publication (3)
CD
FTIR
NMR
Absorbance /
Fluorescence
Interaction protein (1)
Interaction protein (2)
Interaction protein (3)
Interaction protein (4)
PDB (1)
PDB (2)
PDB (3)
Expression tissues
Expression cell lines
Expression plasmids
Level of expression
Channel quaternary
Agonists
Smile agonist
Antagonists and blockers
Open channel blockers identified from a library of triazines
Most active compound: triazine 8aA
Patent application: Antagonistas de TRPV1 y sus usos
Ferrer Montiel Antonio, Fernández Carvajal Asia, González Ros José Manuel, Belmonte Martínez Carlos, Viana de la Iglesia Félix, Gomis Garcia Ana, Messeguer Peypoch Angel, Bujons Vilas Jordi, Vidal Mosquera Miguel, Planells Cases Rosa.
Solicitud No. P201130537 presentada el 5 de abril de 2011.

Publication: Vidal, M., Fernandez-Carvajal, A., Moure, A., Gomis, A., Valente, P., Viana, F., Planells-Cases, R., González-Ros, J.M., Belmonte, C., Bujons, J., Ferrer-Montiel, A., Messeguer, A. Triazine-based Open Channel Receptor Blockers: Design, Synthesis, Evaluation and SAR data. J. Med. Chem. 2011, in press.
Smile antagonist
triazine 8aA: FC1=CC=C(C=C1)CCNC2=NC(NCCCN(C)C)=NC(NCCC3=CC=C(C=C3)F)=N2
Structure-function
relationship
Molecular determinant assembly
Molecular determinant clustering
Molecular determinant trafficking
Molecular determinant binding
Mutants constructs
Antibodies
Diseases

 

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